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The Observer

News and Views from Around the World

Recognition of Genital Differences Among 47XXY Infants

Individuals with KS have a highly varied phenotype comprising a range of physical features, however, genital differences are rarely reported as characteristics feature of the syndrome in childhood. Clinicians need to be aware of the phenotypic variability of KS and recognize KS as one of the causes of abnormal genitalia at birth. This finding, along with appropriate genetic counselling, suggest that early detection of KS is important in monitoring potential development problems; such as hypogonadism, gynecomastia and gender dysphoria in the future.