We know exogenous Testosterone will cause a body to virilise, we also know or should know the extent of which is regulated by several factors ranging from the number of Androgen Receptors to the presence or absence of SRY (testes determining factor) to X chromosome inactivation, and to the Short Stature Homeobox-containing gene (SHOX).
Specialist Clinicians know of these issues and yet the onus of a “good or bad” response is placed firmly on the individual even though they themselves would not be aware of the above mechanisms, invariably resulting in success or failure. Spare a thought then for the impact potent androgens might have outside of virilisation, such as on the biological self, an area that’s poorly understood and worse falsely asserted to benefit bone and metabolic health when there is no evidence this is true, certainly not amongst an XXY population where three sex chromosomes are active in every cell leading to an “all-over” body experience different to the binary sexes. As a community, we deserve far more than a long-held presumption that XXY’s are males with an additional X chromosome and thus “likely” to benefit from the administration of exogenous testosterone, when this is simply not the case for a large percentage of the population, thus highlighting just how crucial research of this nature is. If you are a researcher and interested in changing an outdated understanding of androgens, as they pertain to XX’s and XXY’s then, we urge you to contribute your voice, we have a lot of catching up to do.
The Editors of Biology of Sex Differences extend an invitation to submit original research articles related to sex differences in response to androgens (both physiological and pathophysiological). Androgen supplements are given to men with low or reduced levels of testosterone. They are also given to biological women who are transitioning to become trans-men. However, the mechanisms by which androgens affect organ systems are unknown. Moreover, whether responses to androgens differs in males and females is also unknown. We hope to create a collection of original research articles alongside some commissioned reviews on this important topic and invite researchers in this area to submit to the journal.
All manuscripts will undergo normal peer-review and will be available online on the journal’s website. Manuscripts can be submitted at any time, but to be considered for inclusion in this special collection they must be submitted by December 1, 2019.
Unlike any other scientific journal, Biology of Sex Differences focuses on sex differences in physiology, behaviour, and disease, from molecules to phenotypes, and incorporates basic and clinical research. The journal aims to improve understanding of basic principles and foster development of therapeutic and diagnostic tools that are specific for sex differences. This open-access journal is the highly respected official journal of the Organization for the Study of Sex Differences and is co-published by the Society for Women’s Health Research.