The behavioural profile of children aged 1–5 years with sex chromosome trisomy (47,XXX , 47,XXY , 47,XYY )

Children with SCT have an increased risk of suboptimal neurodevelopment. Previous studies have shown an elevated risk for neurobehavioral problems in individuals with SCT. However, not much is known about neurobehavioral problems in very young children; knowledge that could help with early identification of children at risk for suboptimal development, and that could help establish targets for early intervention. This study addressed the question of what the behavioural profile of children with SCT aged 1–5 years looks like. In total, 182 children aged 1–5 years participated in this study. Recruitment and assessment took place in the Netherlands and the United States. The SCT group was recruited through prospective follow‐up (50%), information seeking parents (31%), and clinical referral (18%). Behavioural profiles were assessed with the child behaviour checklist and the ages‐and‐stages social–emotional questionnaire.

Levels of parent‐rated problem behaviour were higher in children with SCT. Difficulties with overall social–emotional functioning were already present in 1‐year‐olds, and elevated scores were persistent across the full age range. Affective and pervasive developmental behaviours were seen in late toddler-hood and prominent at preschool age. Anxiety, attention deficit, and oppositional defiant behaviours were seen in preschool‐aged children. Within this cross‐sectional study, the developmental trajectory of affective, pervasive developmental, and oppositional defiant behaviours seemed to be different for SCT children than nonclinical controls

Collectively, these results demonstrate the importance of behavioural screening for behavioural problems in routine clinical care for children with SCT from a young age. Social–emotional problems may require special attention, as these problems seem most prominent, showing increased risk across the full age range, and with these problems occurring regardless of the timing of diagnosis, and across all three SCT karyotypes.

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One thought on “The behavioural profile of children aged 1–5 years with sex chromosome trisomy (47,XXX , 47,XXY , 47,XYY )

  1. Well we left a long reply and then got snagged by sign in – bull shit … damned if we’ll write it all over again. Suffice it to say – this is more skullduggery by “professionals” aimed at targeting TRISOMY children for more “billable hours” by psychologists and psychiatrists of questionable training in emotional intelligence while assuming that the parental, relative, and general environment of the particular child is “normal”. Sorry, wrong number.
    A lot of xxys are hyper empathic and they internalize the emotions projected at them (often by people who do not know they are doing so – or are in denial about such behavior). Since the children have little or no language to deal with the hows and wherefores of their perceived feelings they assume responsibility for the way others feel. By age three this can be a major stumbling block to so-called “normal” or unfeeling behavior.
    This study is an excellent intro to the same kind of studies done with mazes and rats in the fifties… mazes were open to the room or sky and the rats used the ceiling and lights to “map” the maze – or if the people doing the study were completely insane they followed the scent markings of the previous rats. In this study the clinicians do not appear to be taking the parents’ emotional states, or their own, and their desire to get results, into account.


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