onevoice47xxy

Non-invasive Breast Cancer Test Is On The Horizon

by onevoice47xxy25/11/202025/11/2020

The non-invasive Breast Screening device has arrived, and will no doubt prove a saviour to an XXY community who do not fit the criteria for annual breast check-ups offered to females yet are equally exposed to a Breast Cancer risk.Getting…

High Dose Fish Oil Does Not Reduce Risk of Cardiac Events

by onevoice47xxy17/11/2020

Many people take fish oil supplements to try to improve various aspects of their health, but new work from the Cleveland Clinic has suggested that high doses of an omega-3 fatty acid supplement don't help people at high risk of…

Recognition of Genital Differences Among 47XXY Infants

by onevoice47xxy07/11/202010/11/2020

Individuals with KS have a highly varied phenotype comprising a range of physical features, however, genital differences are rarely reported as characteristics feature of the syndrome in childhood. Clinicians need to be aware of the phenotypic variability of KS and recognize KS as one of the causes of abnormal genitalia at birth. This finding, along with appropriate genetic counselling, suggest that early detection of KS is important in monitoring potential development problems; such as hypogonadism, gynecomastia and gender dysphoria in the future.

Evidence For Long Noncoding RNA Up-regulation in Klinefelter Syndrome

by onevoice47xxy07/11/202007/11/2020

Klinefelter syndrome (KS) is characterized by the presence of at least one supernumerary X chromosome. KS typical symptoms include tall stature, gynecomastia, hypogonadism and azoospermia. KS patients show a higher risk of developing metabolic and cardiovascular diseases, inflammatory and autoimmune disorders, osteoporosis and cancer.

The X Chromosome: Sex-specific Effects in Infectious Disease

by onevoice47xxy07/11/202007/11/2020

While the X Chromosome Inactivation process in humans is not yet fully understood, studies of human aneuploidy indicate that in a diploid human cell there is always just one active X chromosome in either sex. In Turner syndrome, individuals have only one sex chromosome (one X chromosome, X0) which is kept active, while in males with Klinefelter syndrome (XXY) one X chromosome is silenced. This suggests that the human XCI mechanisms protect one X chromosome while inactivating all others.

Remembering Fred Diener

by onevoice47xxy25/10/202028/11/2020

The XXY community mourns the passing of Fred Diener an XXY trailblazer of San Diego, California, who died on the 23rd of October, aged sixty-five years. Long before KS&A (AXYS) Fred was a pioneer for the XXY community running a support group for Southern California and featured in several news articles of that era about living with XXY.

Prostate Cancer, Gender Identity, and Testosterone Replacement Therapy in Klinefelter Syndrome

by onevoice47xxy16/10/202002/11/2020

In the remaining three cases, there was no mention of TRT. We were unable to find a case where TRT was re-initiated in a patient with KS post cancer treatment, as was our patient’s wish

U.N Human Rights Council to Investigate Violations and Abuses Against Intersex Persons.

by onevoice47xxy02/10/202004/10/2020

The Vienna Declaration states that human rights are universal, indivisible, interdependent and interrelated. The VDPA makes clear that “every person is born equal and has the same rights to life and welfare, education and work, living independently and active participation…

Florida Judge Grants Intersex Woman’s Gender Marker Change Request

by onevoice47xxy30/09/202010/11/2020

Mayfield, who is intersex, was born 47XXY, meaning she has one additional sex chromosome. This left Mayfield neither completely biologically male nor female, but both. Raised male by her parents, Mayfield transitioned to female after having to be placed on estrogen due to health problems and to save her life.

Depression Causes Inflammation and Metabolic Imbalances

by onevoice47xxy18/09/2020

For those in the community who find themselves piling on weight with or without of exogenous sex hormones, could this be a more probably cause? Scientists have discovered that depressed individuals show higher levels of inflammation as well as elevated…

Advocacy + Peer Support

Reach Out is Australia’s leading online mental health organisation for young people and their parents. Our practical support, tools and tips help young people get through anything from everyday issues to tough times – and the information we offer parents makes it easier for them to help their teenagers, too.

YOUth & I seeks to encourage young intersex people to share their own stories, short essays, reflections, poems, cartoons, drawings – really, anything that can be printed! We want to hear from intersex young people everywhere about their experiences, hopes, fears and dreams.

Re-imagine Today is co-designed with people living with mental health issues. Many of those involved have lived experience of the NDIS and have used this experience to help you better understand how it all works

Intersex Peer Support Australia is a peer support, information and advocacy group for people born with variations in sex characteristics and their families.

Intersex Head To Health is a digital Mental Health resource by the Australian Government connecting you with some of Australia’s most trusted Mental Health organisations. It brings together apps, online programs, online forums, and phone services, as well as a range of digital information resources.

Parents of Gender Diverse Children provides peer support to Parents and those parenting Trans and Gender Diverse children. They realise that parents who are well supported are better able to support their children.

Intersex Human Rights Australia promote human rights, health and bodily autonomy. Their goals are to help create a society where intersex bodies are not stigmatised, and where our rights as people are recognised. They build community, evidence, capacity, and education and information resources.

Kids Helpline is Australia’s only free, private and confidential 24/7 phone and online counselling service for young people aged 5 – 25

The Pinnacle Foundation provides multi-year educational scholarships and mentoring support to young adults (between the ages of 17 and 26) across Australia where their sex characteristics have prevented or hindered the achievement of their career aspirations or personal development. Scholarships include a case component and support from a mentor.

Flourish Australia: Being part of the Flourish Australia family is a great way to make new friends, try new things and get more involved with your local community. Connect with us to start feeling less isolated.

Rape and Domestic Violence Services Australia We provide nationwide counselling and support for people impacted by domestic and family violence.

Other Chromosome Variations

46 XX(y) Phenotypically there are three groups of sex-reversed 46,XX individuals. The first classical group includes phenotypically normal XX males, while the second and third groups consist of those with varying forms of genital ambiguity.

48 XXYY is a chromosomal variation that causes infertility, developmental and behavioural issues, as well as other health problems

48,XXXY often compared with 47,XXY because of shared features including tall stature and hypogonadism, 48,XXYY, 48,XXXY and 49,XXXXY are associated with additional physical findings, congenital differences, medical problems and psychological features.

Musculoskeletal Differences Among XXXXY Data was collected from an international cohort of XXXXY’s over 10 years indicating the necessity for comprehensive multidisciplinary treatment.

Educational Resources

Diversitywise Educational Services provides curriculum, pedagogy and professional development services to early learning centres and schools.

Speech & Language Development Australia is the nation’s peak body supporting and advocating for the needs of children and young people with speech, language and related differences.

A Podcast Initiative by The National Consistent Collection of Data on School Students with Disability, to assist in learning more about development issues

Brain Facts dot Org
shares the stories of scientific discovery and the knowledge they reveal. Join them as they explore the universe between our ears. Because when we know our brains, we know ourselves.

Executive dysfunction and relation with behavioral problems .These findings suggest that executive dysfunction may be part of the phenotype of children with an extra X chromosome, impacting the ability to function adequately in everyday life.

International Links

Interesting Facts About XXY: The primary purpose of this blog is to raise awareness of XXY and the difficulties the community faces in finding appropriate medical professionals who understand the multifaceted presentation of what it means to be an XXY individual.

The Organization for the Study of Sex Differences (OSSD) is a unique scientific organization that seeks to enhance knowledge of sex/gender differences by facilitating interdisciplinary communication and collaboration among scientists and clinicians of diverse backgrounds.