Fertility Rates Among Non-Mosaic XXY; At Odds With Real Life Experience

Klinefelter syndrome (KS) is the one of the most frequent chromosomal disorder affecting 1/500–600 male newborns in the general population. The vast majority of the cases shows the 47,XXY karyotype, although mosaicism (46,XY/47,XXY) or higher-grade X aneuploidies can be rarely…

Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism

Is clinical prescription of testosterone therapy associated with short-term risk of venous thromboembolism in men with and without hypogonadism? In this case-crossover study comparing 6-month testosterone use for 39,622 men who had a venous thromboembolism with testosterone use 6 to…

Intersex: Implications of Umbrella Terms in The Interest of Science.

The intersection of science and identity intensifies the complexity of the umbrella term DSD (Disorders of Sex Development)/Intersex. The interest of science to classify DSD/Intersex conditions to formulate evidence-based best practice has implications on personal identity. Fundamental to ethical decision-making…

47XXY and Deep Venous Thrombosis – Support

Klinefelter’s syndrome: Associations with increased blood clot (thrombosis)events (deep venous thrombosis, pulmonary embolus, venousthromboembolism). Free consultation and evaluation. The close association of Klinefelter’s syndrome (47XXY) with unexplained thrombosis has been known for at least 33 years. Venous thromboemboli (VTE) are…