Increased risk of Venous Thrombosis in XXY/KS further exacerbated by testosterone therapy

This study demonstrates poor awareness of the known VTE risks in KS and the potential VTE risks of TT within this cohort. Patients not informed of the inherent risks associated with their condition may be less vigilant to complications, unaware of lifestyle decisions affecting risks, and not able to make informed decisions about medical care. … Continue reading Increased risk of Venous Thrombosis in XXY/KS further exacerbated by testosterone therapy

Pulmonary Embolism in a Patient with Klinefelter’s Syndrome

BACKGROUND Dyspnoea and syncope are common causes of admission to hospitals. Pulmonary embolism is often a differential diagnosis, and by examining the clinical history the clinician searches for known predisposing factors. This case report highlights the importance of Klinefelter’s syndrome as a predisposing factor for venous thromboembolism. The syndrome is caused by an extra X … Continue reading Pulmonary Embolism in a Patient with Klinefelter’s Syndrome

High Dose Fish Oil Does Not Reduce Risk of Cardiac Events

Many people take fish oil supplements to try to improve various aspects of their health, but new work from the Cleveland Clinic has suggested that high doses of an omega-3 fatty acid supplement don't help people at high risk of cardiovascular events reduce their risk of those events. The conclusions are from the STRENGTH Trial: … Continue reading High Dose Fish Oil Does Not Reduce Risk of Cardiac Events

Evidence For Long Noncoding RNA Up-regulation in Klinefelter Syndrome

Klinefelter syndrome (KS) is the most common sex-chromosome variation among males, with an estimated prevalence of 1:660 newborns. The most common karyotype is the classic 47,XXY, which accounts for the 80–90% of all cases. It is a consequence of a non-disjunction of paired X-chromosomes during the first or second meiotic division, equally due to a … Continue reading Evidence For Long Noncoding RNA Up-regulation in Klinefelter Syndrome

Combating Metabolic Disease

The Centres for Disease Control and Prevention (CDC) estimates that in 2018, obesity impacted about 42 percent of American adults. People with obesity are at higher risk for many diseases, including type 2 diabetes, coronary heart disease, and stroke; they also tend to generally have a lower quality of life and a higher risk of death. As of 2008, … Continue reading Combating Metabolic Disease

The Promises and Pitfalls of Sex Difference Research

It's been hypothesised that XXY's are biological females dressed in male clothing, that being so we ask you keep in mind when reading how an XXY experience might have greater similarity to females than males, of course none of this would be necessary if researches were to include Intersex as a variable. Still comparing the … Continue reading The Promises and Pitfalls of Sex Difference Research

Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism

Is clinical prescription of testosterone therapy associated with short-term risk of venous thromboembolism in men with and without hypogonadism? In this case-crossover study comparing 6-month testosterone use for 39,622 men who had a venous thromboembolism with testosterone use 6 to 12 months before the venous thromboembolism, use of testosterone therapy in the 6-month case period … Continue reading Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism

47XXY and Deep Venous Thrombosis – Support

Klinefelter’s syndrome: Associations with increased blood clot (thrombosis)events (deep venous thrombosis, pulmonary embolus, venousthromboembolism). Free consultation and evaluation. The close association of Klinefelter’s syndrome (47XXY) with unexplained thrombosis has been known for at least 33 years. Venous thromboemboli (VTE) are ~20 fold more frequent in Klinefelter’s syndrome than in the general population. Previous single case … Continue reading 47XXY and Deep Venous Thrombosis – Support

How broken sleep promotes cardiovascular disease

Given the high incidence of Sleep Apnoea amongst XXY's administering exogenous Testosterone, research of this nature would seem to indicate a far greater impact than insomnia alone. Most people have at some point echoed Macbeth’s complaint about the loss of “sleep that knits up the ravelled sleeve of care”. Sleep disorders, such as obstructive sleep … Continue reading How broken sleep promotes cardiovascular disease