Children – The XXY Project

Recognition of Genital Differences Among Some 47XXY Infants

by onevoice47xxy07/11/202019/12/2020

Klinefelter syndrome (KS) is a sex chromosome variation caused by the presence of one or more supernumerary X chromosomes. Common clinical phenotypes of KS are comprised of tall stature with a feminine body type, gynecomastia, small testes and infertility. Cases…

Exogenous Testosterone is not a requirement of 47XXY’s at Mini and Pre‑Puberty

by onevoice47xxy17/05/202027/07/2020

The hypothalamus–pituitary–gonadal axis (HPG) during mini-puberty in boys with KS has been evaluated by several investigative groups and “all” possible results recorded: above normal, below normal or indistinguishable from normal (Aksglaede, Petersen, Main, Skakkebæk, & Juul, 2007; Lahlou, Fennoy, Ross,…

Fertility Rates Among Non-Mosaic XXY; At Odds With Real Life Experience

by onevoice47xxy05/02/202020/03/2020

Klinefelter syndrome (KS) is the one of the most frequent chromosomal disorder affecting 1/500–600 male newborns in the general population. The vast majority of the cases shows the 47,XXY karyotype, although mosaicism (46,XY/47,XXY) or higher-grade X aneuploidies can be rarely…

What We Would Like Doctors To Know About XXY

by onevoice47xxy28/10/201923/02/2020

If you are a Doctor And consider yourself an expert in all things XXY, then you will never learn anything about us. Adult XXY's often have adversarial relationships with physicians. If you have a patient like that, don't take it…

New DNA ‘clock’ could help measure development in young children

by onevoice47xxy17/10/201921/10/2019

Scientists have developed a molecular "clock" that could reshape how paediatricians measure and monitor childhood growth and potentially allow for an earlier diagnosis of life-altering development disorders. The research, published this week in PNAS, (Full Study) describes how the addition of…

What are the Differences Between Developmental Language Disorder (DLD) and Autism Spectrum Disorder (ASD)

by onevoice47xxy30/09/201919/12/2020

Neurodevelopmental conditions is a name doctors and scientists give to differences from the expected brain and behaviour development during childhood. There are many ways that brain development can be different. One of the most well known neurodevelopmental conditions is autism, which has some similarities with Developmental Language Disorder (DLD), but also some important differences.

Dyspraxia is more than just “clumsy child syndrome” – it can cause emotional distress and anxiety throughout life

by onevoice47xxy01/09/201928/02/20201 Comment

Ring all the bells, that still can ring, this could well be a story typical of an XXY experience, albeit one without an additional diagnosis. Of note is how the article is extremely well researched with an abundance of additional…

Understanding Conversation – Children With an Extra X or Y Chromosome – Now Recruiting!

by onevoice47xxy30/08/201914/09/2019

The Department of Experimental Psychology (EP) at the University of Oxford would like to invite your child to be part of this study investigating how we understand conversation. The project is looking at how children understand conversations. We know that vocabulary and…

Chromosome Variant Factsheet

by onevoice47xxy09/08/201908/11/2019

At the XXY Project we are anti anything that depicts Chromosome Variations of any description as being abnormal because what they're describing is not the natural variation these differences are but rather something that's broken and something that needs to…

Interview: David Cooke on 47XXY

by onevoice47xxy29/05/201914/09/2019

Had he been practising some forty years ago, pediatric endocrinologist David Cooke’s profile of patients who are 47XXY would have differed sharply from today’s view. Then, late-adolescent boys would have comprised most of Cooke’s patients. Now, with amniocentesis and prenatal karyotyping…

Advocacy + Peer Support

Reach Out is Australia’s leading online mental health organisation for young people and their parents. Our practical support, tools and tips help young people get through anything from everyday issues to tough times – and the information we offer parents makes it easier for them to help their teenagers, too.

Re-imagine Today is co-designed with people living with mental health issues. Many of those involved have lived experience of the NDIS and have used this experience to help you better understand how it all works

Intersex Peer Support Australia is a peer support, information and advocacy group for people born with variations in sex characteristics and their families.

Kids Helpline is Australia’s only free, private and confidential 24/7 phone and online counselling service for young people aged 5 – 25

Intersex Head To Health is a digital Mental Health resource by the Australian Government connecting you with some of Australia’s most trusted Mental Health organisations. It brings together apps, online programs, online forums, and phone services, as well as a range of digital information resources.

Parents of Gender Diverse Children provides peer support to Parents and those parenting Trans and Gender Diverse children. They realise that parents who are well supported are better able to support their children.

Intersex Human Rights Australia promote human rights, health and bodily autonomy. Their goals are to help create a society where intersex bodies are not stigmatised, and where our rights as people are recognised. They build community, evidence, capacity, and education and information resources.

Flourish Australia: Being part of the Flourish Australia family is a great way to make new friends, try new things and get more involved with your local community. Connect with us to start feeling less isolated.

Rape and Domestic Violence Services Australia We provide nationwide counselling and support for people impacted by domestic and family violence.

Other Sex Chromosome Variations

46 XX(y) Phenotypically there are three groups of sex-reversed 46,XX individuals. The first classical group includes phenotypically normal XX males, while the second and third groups consist of those with varying forms of genital ambiguity.

48 XXYY is a chromosomal variation that causes infertility, developmental and behavioural issues, as well as other health problems

48,XXXY often compared with 47,XXY because of shared features including tall stature and hypogonadism, 48,XXYY, 48,XXXY and 49,XXXXY are associated with additional physical findings, congenital differences, medical problems and psychological features.

Educational Resources

Diversitywise Educational Services provides curriculum, pedagogy and professional development services to early learning centres and schools.

Speech & Language Development Australia is the nation’s peak body supporting and advocating for the needs of children and young people with speech, language and related differences.

A Podcast Initiative by The National Consistent Collection of Data on School Students with Disability, to assist in learning more about development issues

Brain Facts dot Org
shares the stories of scientific discovery and the knowledge they reveal. Join them as they explore the universe between our ears. Because when we know our brains, we know ourselves.

Executive dysfunction and relation with behavioral problems .These findings suggest that executive dysfunction may be part of the phenotype of children with an extra X chromosome, impacting the ability to function adequately in everyday life.

International Links

Interesting Facts About XXY: The primary purpose of this blog is to raise awareness of XXY and the difficulties the community faces in finding appropriate medical professionals who understand the multifaceted presentation of what it means to be an XXY individual.

The Organization for the Study of Sex Differences (OSSD) is a unique scientific organization that seeks to enhance knowledge of sex/gender differences by facilitating interdisciplinary communication and collaboration among scientists and clinicians of diverse backgrounds.