Exogenous Testosterone is not a requirement of 47XXY’s at Mini and Pre‑Puberty

The hypothalamus–pituitary–gonadal axis (HPG) during mini-puberty in boys with KS has been evaluated by several investigative groups and “all” possible results recorded: above normal, below normal or indistinguishable from normal (Aksglaede, Petersen, Main, Skakkebæk, & Juul, 2007; Lahlou, Fennoy, Ross,…

Fertility Rates Among Non-Mosaic XXY; At Odds With Real Life Experience

Klinefelter syndrome (KS) is the one of the most frequent chromosomal disorder affecting 1/500–600 male newborns in the general population. The vast majority of the cases shows the 47,XXY karyotype, although mosaicism (46,XY/47,XXY) or higher-grade X aneuploidies can be rarely…

New DNA ‘clock’ could help measure development in young children

Scientists have developed a molecular "clock" that could reshape how paediatricians measure and monitor childhood growth and potentially allow for an earlier diagnosis of life-altering development disorders. The research, published this week in PNAS, (Full Study) describes how the addition of…

What are the Differences Between Developmental Language Disorder (DLD) and Autism Spectrum Disorder (ASD)

Neurodevelopmental conditions is a name doctors and scientists give to differences from the expected brain and behaviour development during childhood.  There are many ways that brain development can be different. One of the most well known neurodevelopmental conditions is autism,…

Dyspraxia is more than just “clumsy child syndrome” – it can cause emotional distress and anxiety throughout life

Ring all the bells, that still can ring, this could well be a story typical of an XXY experience, albeit one without an additional diagnosis. Of note is how the article is extremely well researched with an abundance of additional…

Understanding Conversation – Children With an Extra X or Y Chromosome – Now Recruiting!

The Department of Experimental Psychology (EP) at the University of Oxford would like to invite your child to be part of this study investigating how we understand conversation. The project is looking at how children understand conversations. We know that vocabulary and…