The X Chromosome: Sex-specific Effects in Infectious Disease

The X chromosome and X-linked variants have largely been ignored in genome-wide and candidate association studies of infectious diseases due to the complexity of statistical analysis of the X chromosome. This exclusion is significant, since the X chromosome contains a high density of immune-related genes and regulatory elements that are extensively involved in both the … Continue reading The X Chromosome: Sex-specific Effects in Infectious Disease

Human Sex Chromosome Swapping Occurs More Often Than Previously Thought

It turns out that the rigid "line in the sand" over which the human sex chromosomes -- the Y and X -- go to avoid crossing over is a bit blurrier than previously thought. Contrary to the current scientific consensus, Arizona State University assistant professor Melissa Wilson Sayres has led a research team that has … Continue reading Human Sex Chromosome Swapping Occurs More Often Than Previously Thought

History of The Research on Sex Determination

Since the beginning of humanity, people were fascinated by sex and intrigued by how the differences between sexes are determined. Ancient philosophers and middle age scholars proposed numerous fantastic explanations for the origin of sex differences in people and animals. However, only the development of the modern scientific methods allowed us to find, on the … Continue reading History of The Research on Sex Determination

XXY Trailblazer Steps Up To The Podium

UCF students who worked on the petition gather in support of Juleigh Mayfield (seated by the window) after her hearing Jan. 15 at the Osceola County Courthouse. (Photo by Nick Leyva ’15)

University of Central Florida associate lecturer Irene Pons  and her legal studies class are striving to help a Central Florida woman revise her birth certificate. Why does Juleigh Mayfield need legal intervention in order to complete such an ordinary task? Because her story isn’t so typical. Neither Male or Female Although Mayfield lived four decades of … Continue reading XXY Trailblazer Steps Up To The Podium

Biologists pioneer first method to decode gene expression

Given the recent remarkable advancements in genetics, it's easy to assume that 21st century scientists have at their disposal a clear, quick way to run a genomic sequence scan and find out which genes among thousands can be expressed and which cannot. Gene expression is the process by which information encoded within genes leads to … Continue reading Biologists pioneer first method to decode gene expression

How science has shifted our sense of identity

Across the arc of the past 150 years, we can see both science and scientism shaping human identity in many ways. Developmental psychology zeroed in on the intellect, leading to the transformation of IQ (intelligence quotient) from an educational tool into a weapon of social control. Immunology redefined the ‘self’ in terms of ‘non-self’. Information … Continue reading How science has shifted our sense of identity

New Mutations Appear in the Sperm and Eggs of Parents

Although long established how age can play a part in the creation of sex variants, researchers have always refrained from blaming either parent outright insisting instead on a 50/50 approach (it keeps marriages together). But now it seems there's a third possibility, that of the fetus itself . What if sex chromosome variants weren't the … Continue reading New Mutations Appear in the Sperm and Eggs of Parents

New DNA ‘clock’ could help measure development in young children

Scientists have developed a molecular "clock" that could reshape how paediatricians measure and monitor childhood growth and potentially allow for an earlier diagnosis of life-altering development disorders. The research, published this week in PNAS, (Full Study) describes how the addition of chemical tags to DNA over time can potentially be used to screen for developmental differences … Continue reading New DNA ‘clock’ could help measure development in young children

The Genetic Origins of Sex Differences in Disease

It took almost 15 years for scientists to sequence and publish a complete accounting of the human genetic code — the 3 billion base pairs along the double strands of DNA that serve as a blueprint for the body’s functions and pass traits from parents to offspring. Now, approximately 15 years after the human genome … Continue reading The Genetic Origins of Sex Differences in Disease

Understanding Conversation – Children With an Extra X or Y Chromosome – Now Recruiting!

The Department of Experimental Psychology (EP) at the University of Oxford would like to invite your child to be part of this study investigating how we understand conversation. The project is looking at how children understand conversations. We know that vocabulary and grammar are important in understanding conversation, but social communication is likely to depend on more … Continue reading Understanding Conversation – Children With an Extra X or Y Chromosome – Now Recruiting!

47XXY: So Much More Than Hypogonadism

The spectrum of neuropsychological phenotypes47XXY has been traditionally associated with a particular neuropsychological phenotype, including deficits in specific domains of cognition, mainly regarding verbal processing abilities and adaptation problems as well as attention deficits and social skill impairments. As a consequence, XXY individuals are prone to suffering from learning difficulties and their achievements regarding academic … Continue reading 47XXY: So Much More Than Hypogonadism

Invasive Tumbleweed Demonstrates the Advantage of Extra Chromosomes

We don't get Tumbleweed in this part of the world but for those of you who might see it as a nuisance, next time you see one....or maybe two tumbling across the road in harmony, then this research just might give you cause to look on in amazement and maybe bring some home with you. … Continue reading Invasive Tumbleweed Demonstrates the Advantage of Extra Chromosomes

New Techniques are Providing Unprecedented Views into Human Development – Raising Ethical Questions.

For two tense weeks in mid-2013, developmental biologist Magdalena Zernicka-Goetz was chasing a world record. She and her colleagues at the University of Cambridge, UK, were attempting to grow human embryos in the lab for longer than had ever been done before. They wanted to glean insights into how a tiny blob of cells transforms … Continue reading New Techniques are Providing Unprecedented Views into Human Development – Raising Ethical Questions.

Chromosome Variant Factsheet

At the XXY Project we are anti anything that depicts Chromosome Variations of any description as being abnormal because what they're describing is not the natural variation these differences are but rather something that's broken and something that needs to be fixed. Medical Science, Clinicians and the like are steadfastly stuck on the notion that … Continue reading Chromosome Variant Factsheet