Klinefelter syndrome (KS) is the most common sex-chromosome variation among males, with an estimated prevalence of 1:660 newborns. The most common karyotype is the classic 47,XXY, which accounts for the 80–90% of all cases. It is a consequence of a non-disjunction of paired X-chromosomes during the first or second meiotic division, equally due to a … Continue reading Evidence For Long Noncoding RNA Up-regulation in Klinefelter Syndrome
FOR Arman Raznahan, publishing research on sex differences is a fraught proposition. Now chief of the section on developmental neurogenomics at the National Institutes of Health, Raznahan learned early that searching for dissimilarities between men’s and women’s brains can have unintended effects.“I got my fingers burned when I first started,” Raznahan says. As a PhD student, … Continue reading Study Finds Sex Differences in the Brain. Does It Matter?
It turns out that the rigid "line in the sand" over which the human sex chromosomes -- the Y and X -- go to avoid crossing over is a bit blurrier than previously thought. Contrary to the current scientific consensus, Arizona State University assistant professor Melissa Wilson Sayres has led a research team that has … Continue reading Human Sex Chromosome Swapping Occurs More Often Than Previously Thought
Since the beginning of humanity, people were fascinated by sex and intrigued by how the differences between sexes are determined. Ancient philosophers and middle age scholars proposed numerous fantastic explanations for the origin of sex differences in people and animals. However, only the development of the modern scientific methods allowed us to find, on the … Continue reading History of The Research on Sex Determination
Given the recent remarkable advancements in genetics, it's easy to assume that 21st century scientists have at their disposal a clear, quick way to run a genomic sequence scan and find out which genes among thousands can be expressed and which cannot. Gene expression is the process by which information encoded within genes leads to … Continue reading Biologists pioneer first method to decode gene expression