A Rare Breed

A Rare Breed introduces us to Rob Wilson (47XXY), a Tasmanian Chicken and Pig breeder. Rob was born with dual male and female gonads and underwent surgery as a child to present more male-like in appearance. With the assistance of fertility treatments, he went on to ‘father’ children and, by all accounts thereafter has lived …

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Weapon Grave at Suontaka Vesitorninmäki, Finland

In 1968, a weapon grave with brooches was found at Suontaka Vesitorninmäki, Hattula, Finland. Since then, the grave has been interpreted as evidence of powerful women, even female warriors and leaders in early medieval Finland. Others have denied the possibility of a woman buried with a sword and tried to explain it as a double …

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Exogenous Testosterone is not a requirement of 47XXY’s at Mini and Pre‑Puberty

The hypothalamus–pituitary–gonadal axis (HPG) during mini-puberty in boys with KS has been evaluated by several investigative groups and “all” possible results recorded: above normal, below normal or indistinguishable from normal (Aksglaede, Petersen, Main, Skakkebæk, & Juul, 2007; Lahlou, Fennoy, Ross, Bouvatier, & Roger, 2011; Ross et al., 2005). None of these studies has enough boys …

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Fertility Rates Among Non-Mosaic XXY; At Odds With Real Life Experience

Klinefelter syndrome (KS) is one of the most frequent chromosomal disorders affecting 1/500–600 male newborns in the general population. The vast majority of the cases show the 47, XXY karyotype, although mosaicism (46, XY/47, XXY) or higher-grade X aneuploidies can rarely be detected. Despite its high incidence, KS frequently remains undiagnosed, and it is suspected …

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Cognitive and Neurological Aspects of Sex Chromosome Variations

Sex chromosome variations (SCV) are characterised by an atypical variation in the number or function of sex chromosomes. They are some of the most common genetic differences in human beings, and include 47 XXY; one in six hundred live births, 45X ; one in two thousand and 47 XYY; one in one thousand. However, by …

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The Genetic Origins of Sex Differences in Disease

It took almost 15 years for scientists to sequence and publish a complete accounting of the human genetic code — the 3 billion base pairs along the double strands of DNA that serve as a blueprint for the body’s functions and pass traits from parents to offspring. Now, approximately 15 years after the human genome …

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