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Promoting Awareness of 47 XXY

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  • What is 47, XXY
  • Our Journey’s
    • Part 1
      • The Climb.
      • Caught Between
      • Lost and Found
      • Everything Is Clearer Now
      • We Are One
      • Venture a Highway
      • Silent Tears
      • Watching, Waiting
      • Living with My Son – A True Adventure
    • Part 2
      • Something Isn’t Right
      • Reflecting on better times
      • In A State of Perpetual Motion
      • Finding My Way
      • I Am Who I Want To Be
      • Finding Me
      • The Calling
      • I’m a Man and a Woman
      • A Tribute
      • Walk With Me
    • Part 3
      • Can you hear me now
      • Being Intersex – A History – A State of Being
      • In Memory
      • Logophilia
      • The Hole In Me to the Whole Me
      • Learning to Fly
      • Just an XXY/Intersex Kind of Guy
      • Late Diagnosis
      • You Are Not Alone
  • Library
    • Books
      • Living With 47XXY, 47XXX & 47XYY (English with Spanish Translation)
      • The KS Story (You are not alone)
      • Tomorrow
      • Gender Dysphoria Services: A Guide For General Practitioners and Other Healthcare Staff
      • Finding Your Way With ADHD: Struggles, Supports, and Solutions
      • The X in Sex; And How It Controls Our Lives
      • The Masculine Mystique of T
      • The Centenary of Genetics: Bridges to the Future
      • Gregory and his Extra X
      • Guidance on the Assessment and Diagnosis of Intellectual Disabilities in Adulthood
      • Special Brothers and Sisters
    • Health
      • Hormones
        • Oxandrolone Treatment Results in an Increased Risk of Gonadarche in Prepubertal Boys With Klinefelter Syndrome
        • The Role of Hypogonadism in Klinefelter Syndrome
        • Clinical Practice Guideline: Testosterone Therapy in Men with Hypogonadism
      • Cognitive
        • A Review of Neurocognitive Functioning of Children with Sex Chromosome Trisomies
        • Guidance on the Assessment and Diagnosis of Intellectual Disabilities in Adulthood
        • KS Increased Brain Responses Not To Visual Stimuli
        • Understanding Sex Differences to Inform Studies of Diseases of The Nervous System
        • Beyond the Literal Meaning of Words in Children Who Are XXY
        • The behavioural profile of children aged 1–5 years with sex chromosome trisomy (47,XXX , 47,XXY , 47,XYY )
      • Physiology
        • Mortality in Patients with Klinefelter Syndrome in Britain: A Cohort Study
        • Genes Underlying Delayed Puberty
        • Is the prevalence of Klinefelter syndrome increasing?
        • Recent Advances in Managing and Understanding Klinefelter Syndrome
        • Chromosomal Variants Amongst XXY (Klinefelter Syndrome)
        • Clinical Challenges Among 47 XXY Children, Adolescents, and Adults
        • What Is the Biologic Basis of Variations in Sexual Phenotype
        • What microRNAs could tell us about the Human X Chromosome
        • 47XXY and Autoimmune Diseases
        • Are XXY’s more at risk of developing COVID 19?
      • Fertility
        • TESE: When is the right time?
        • So, You Want To Have A Baby?
    • Educational
      • Hormone Replacement Therapy
      • Is the prevalence of Klinefelter syndrome increasing?
      • Chromosomal Variants Amongst XXY (Klinefelter Syndrome)
      • Mary F. Lyon (1925–2014)
      • Recent Advances in Managing and Understanding Klinefelter Syndrome
      • Dr Michael Noble (47XXY)
      • A History of Medical Genetics in Pediatrics
      • Genes Underlying Delayed Puberty
    • In Perspective
      • What we wish doctors knew about XXY
      • Mental Health
      • If you are a parent
      • The XXY Individual
    • Mental Health
      • Mental Health of a Large Group of Adults With Variations of Sex Development in Six European Countries.
      • Autism and social anxiety in children with sex chromosome trisomies: an observational study.
      • The Lived Experience of 47XXY (Klinefelter Syndrome): A Narrative Review of the Literature
      • Neurocognitive underpinnings among 47 XXY’s and the association with mental health problems
      • Anxiety and Depression in Klinefelter Syndrome: The Impact of Personality and Social Engagement
    • Media
      • So you think you know sex?
      • How To Draw a Family Tree
      • Creative Explanation of Klinefelter’s Syndrome
      • What is Intersex
      • X Chromosome Inactivation
      • A Conversation with David Strachan.
      • An XXY woman with a sword: Weapon Grave at Suontaka Vesitorninmäki, Finland
      • Images
    • The Darlington Statement
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Change has a considerable psychological impact on the human mind. To the fearful it is threatening because it means that things may get worse. To the hopeful it is encouraging because things may get better. To the confident it is inspiring because the challenge exists to make things better.

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Advocacy + Peer Support

Cirrus Counselling is managed by an XXY individual with an Accreditation in Mental Health and Social Work.  Specialty areas include Autism Spectrum Disorder (ASD-1) with Adults, Alcohol & Other Drugs, Group Art Therapy, LGBTI, Intersex, and Dream work.

Reach Out is Australia’s leading online mental health organisation for young people and their parents. Our practical support, tools and tips help young people get through anything from everyday issues to tough times – and the information we offer parents makes it easier for them to help their teenagers, too.

Re-imagine Today is co-designed with people living with mental health issues. Many of those involved have lived experience of the NDIS and have used this experience to help you better understand how it all works

Intersex Peer Support Australia is a peer support, information and advocacy group for people born with variations in sex characteristics and their families.

Intersex Head To Health is a digital Mental Health  resource by the Australian Government connecting you with some of Australia’s most trusted Mental Health organisations. It brings together apps, online programs, online forums, and phone services, as well as a range of digital information resources.

Parents of Gender Diverse Children provides peer support to Parents and those parenting Trans and Gender Diverse children. They realise that parents who are well supported are better able to support their children.

Intersex Human Rights Australia promote human rights, health and bodily autonomy. Their goals are to help create a society where intersex bodies are not stigmatised, and where our rights as people are recognised. They build community, evidence, capacity, and education and information resources.

New Access – Mental Health Coaching Support Is a free coaching program, designed to provide accessible, quality services for anyone finding it hard to manage life stress. The program uses Low-intensity Cognitive Behavioural Therapy practices and aims to help people break the cycle of negative or unhelpful thoughts.

The Pinnacle Foundation provides educational scholarships, mentoring and opportunities for young LGBTIQ+ Australians to realise their full potential and overcome challenges. Scholarships are awarded for fulltime study at public institutions of higher education in Australia, for the purpose of gaining an educational or vocational qualification in any profession, trade or the arts.

ADHD Foundation is a volunteer-run organisation working towards creating projects that support the ADHD community in Australia. 

Disability Gateway is a Federal Government initiative that assists all people with disabilities, their families and carers to locate and access services across Australia

 

Understanding 47 XXY

Medical Management of KS among XXY Adults

How To Draw a Family Tree

A Review of Neurocognitive Functioning and Risk for Psychopathology in Sex Chromosome Trisomy XXY, XXX, XYY  

Recent Advances in Managing and Understanding Klinefelter’s Syndrome (47XXY)

Neural Systems for Social Cognition in Klinefelter Syndrome (47,XXY)

A cross-sectional study of early language abilities in children with sex chromosome trisomy (XXY, XXX, XYY) aged 1–6 years

How Sex/Gender Influence Health & Disease

Human X Chromosome Inactivation and Reactivation

A History of Medical Genetics in Pediatrics

Genes Underlying Delayed Puberty

XXY: A Pediatric Quantitative Brain Magnetic Resonance Imaging Case-Control Study

High Normal Testosterone Levels Among Non-Mosaic XXY Infants

Escape from X Chromosome Inactivation: An Evolutionary Perspective

Different paternal origins of  supernumerary X chromosomes among 47XXY brothers

When the Lyon(ized chromosome) roars: ongoing expression from an inactive X chromosome

Reduced Artery Diameters  in Klinefelter’s Syndrome

Gender Dysphoria in Klinefelter’s Syndrome

 

 

Other Sex Chromosome Variations

45 X is a genetic disorder affecting some women and girls. It might cause problems with hearing, vision and infertility, but usually not with intellectual ability. Treatment with hormones can help deal with some of the problems.

46 XX(y) Phenotypically there are three groups of sex-reversed 46,XX individuals. The first classical group includes phenotypically normal XX males, while the second and third groups consist of those with varying forms of genital ambiguity.

46 XX/46 XY  is an exceptionally rare chimeric genetic condition characterized by the presence of some cells that express a 46,XX karyotype and some cells that express a 46,XY karyotype in a single human being.

47 XYY  is caused by having an extra copy of the Y chromosome in every cell of the body. Diagnosis can be made based on prenatal tests, or it may occur during childhood or adulthood if a male has signs or symptoms

48 XXYY  is a chromosomal variation that causes infertility, developmental and behavioural issues, as well as other health problems

48,XXXY  often compared with 47,XXY because of shared features including tall stature and hypogonadism, 48,XXYY, 48,XXXY and 49,XXXXY are associated with additional physical findings, congenital differences, medical problems and psychological features.

Incidence of Sex Chromosome Variations. Knowledge on the prevalence of Sex Chromosome Variations are limited, where delayed diagnosis or non-diagnosis are a continuous concern. We aimed to investigate change over time in incidence, prevalence and age at diagnosis among  XO, XXY, XXX and XYY’s

 

Educational Resources

Diversitywise Educational Services provides curriculum, pedagogy and professional development services to early learning centres and schools.

Speech & Language Development Australia is the nation’s peak body supporting and advocating for the needs of children and young people with speech, language and related differences.

A Podcast Initiative  by The National Consistent Collection of Data on School Students with Disability, to assist in learning more about development issues

Brain Facts dot Org
shares the stories of scientific discovery and the knowledge they reveal. Join them as they explore the universe between our ears. Because when we know our brains, we know ourselves.

Executive dysfunction and relation with behavioral problems .These findings suggest that executive dysfunction may be part of the phenotype of children with an extra X chromosome, impacting the ability to function adequately in everyday life.

Google Tools For Special Needs .This information provides a list of many useful Google-related tools and features for users with special needs. It is a rapidly evolving area, and the list will be updated periodically to reflect the most current, and most valuable resources.

SPD Australia: Supporting and Advocating for people with Sensory Processing Disorder

Sensory Processing Disorder: A checklist to help parents and professionals who interact with children become educated about particular signs of sensory processing dysfunction.

Pharmacology

All you ever needed to know about Pharmacology but were too afraid to ask

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International Links

Interesting Facts About XXY: The primary purpose of this blog is to raise awareness of XXY and the community's difficulties in finding appropriate medical professionals who understand the multifaceted presentation of what it means to be an XXY individual.

Chromo-diversity Clinic: is a Podcast aimed at Clinicians, Therapists & Families which discusses Common Genetic Diversity in Children & Adults. Listen to original articles by world-leading researchers on genetic diversity among X&Y chromosome variations, which are often linked to neurodiversity and other invisible strengths & needs.

Klinefelter Syndrome Association UK is the national association of the UK and Ireland. Its mission is to offer support and understanding to those impacted by KS/XXY and to raise awareness among medical professionals to promote greater research and management.

The Organization for the Study of Sex Differences (OSSD) is a unique scientific organization that seeks to enhance knowledge of sex/gender differences by facilitating interdisciplinary communication and collaboration among scientists and clinicians of diverse backgrounds.

XXYtalk.com is an international support forum for 47XXY, Klinefelter's Syndrome and associated variants.

Just Juleigh is the blog of an XXY individual who hosts regular podcasts promoting Intersex awareness and life's great diversity.

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  • Klinefelter's Syndrome (XXY) by Morgan Peppe
  • So you think you know sex?
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