Mapping the Lived Experiences of Intersex/Variations of Sex Characteristics in Ireland

Kudos to Tanya, Maria, Mel and Anthony at DCU for finalising and publishing this invaluable report in such unprecedented times. It is hoped the finding will lay the groundwork to improve the lived experiences of those not yet diagnosed and all others who have gone unnoticed or have not been able to find resources and … Continue reading Mapping the Lived Experiences of Intersex/Variations of Sex Characteristics in Ireland

A qualitative exploration of gender identity among individuals with Klinefelter’s Syndrome/ 47 XXY.

The University of Derby (United Kingdom) is conducting research to explore the experience of gender identity among KS/XXY individuals and to understand if any of these experiences have affected an individual’s well-being. To understand the psychological support offered to individuals that may have experienced gender identity discomfort or uncertainty at any point in their lifetime

Gender Identity and 47 XXY Survey.

The KS/XXY clinic at St. Thomas’ Hospital in the United Kingdom is seeking your help with conducting some valuable research, part of which includes a questionnaire that seeks to understand the varying gender representations seen amongst 47 XXY's. The findings will be used to determine how the clinic might better support those whose identities differ … Continue reading Gender Identity and 47 XXY Survey.

New DNA ‘clock’ could help measure development in young children

Scientists have developed a molecular "clock" that could reshape how paediatricians measure and monitor childhood growth and potentially allow for an earlier diagnosis of life-altering development disorders. The research, published this week in PNAS, (Full Study) describes how the addition of chemical tags to DNA over time can potentially be used to screen for developmental differences … Continue reading New DNA ‘clock’ could help measure development in young children

The Genetic Origins of Sex Differences in Disease

It took almost 15 years for scientists to sequence and publish a complete accounting of the human genetic code — the 3 billion base pairs along the double strands of DNA that serve as a blueprint for the body’s functions and pass traits from parents to offspring. Now, approximately 15 years after the human genome … Continue reading The Genetic Origins of Sex Differences in Disease

Call For Papers. Sex Differences in Response to Androgens: Physiological and Pathophysiological

We know exogenous Testosterone will cause a body to virilise, we also know or should know the extent of which is regulated by several factors ranging from the number of Androgen Receptors to the presence or absence of SRY  (testes determining factor) to X chromosome inactivation, and to the Short Stature Homeobox-containing gene (SHOX). Specialist Clinicians know … Continue reading Call For Papers. Sex Differences in Response to Androgens: Physiological and Pathophysiological

Invisible Gender in Medical Research

The thing about being XXY and/or variant is how we are continually compared with XY Males even though we are biologically different and respond differently in major health disparities  such as (in this instance) Cardiovascular health and disease. Not helpful to the XXY is a pathological relience on the Y chromosome determining maleness and how … Continue reading Invisible Gender in Medical Research

A Tribute to Patricia Jacobs.

THE WILLIAM ALLAN MEMORIAL AWARDPresented to Patricia A. Jacobs, D.Sc., at the annual meetingof the American Society of Human GeneticsDallas, October 28-31, 1981.Introduction byJOHN L. HAMERTON The presentation of the William Allan Memorial Award is a special occasion each year for this Society. The award has been presented to distinguished human geneticists both from North … Continue reading A Tribute to Patricia Jacobs.

Hyperestrogenism The Elephant in Klinefelter’s Syndrome

Photo Credit: William Daigneault What is clear is that a condition of relative hyperestrogenism is present in these patients, since the estradiol/testosterone ratio is altered thanks to the lower concentrations of total serum testosterone in presence of normal serum estradiol. Accordingly, the results of this study confirm unequivocally the significant reduction in total serum testosterone … Continue reading Hyperestrogenism The Elephant in Klinefelter’s Syndrome

Inside the Experiment That Could End Infertility

IVG uses stem cells — the biological clay that can form every body part — to build sex cells, which in humans are sperm and eggs. If successful, the technique could solve infertility due to age, cancer, or various disorders, which today affects tens of millions of people. It could also stretch the possibilities for genetic kinship and nudge biology … Continue reading Inside the Experiment That Could End Infertility